| Product Name | EFNA1 Antibody |
|---|---|
| Description | Rabbit polyclonal antibody to EFNA1 |
| Synonyms | B61 antibody; ECKLG antibody; EFL 1 antibody; EFL1 antibody; EFNA 1 antibody; Efna1 antibody; EFNA1_HUMAN antibody; EPH related receptor tyrosine kinase ligand 1 antibody; EPH-related receptor tyrosine kinase ligand 1 antibody; Ephrin-A1 antibody; Ephrin-A1, secreted form antibody; EphrinA1 antibody; EPLG 1 antibody; EPLG1 antibody; Immediate early response protein B61 antibody; LERK 1 antibody; LERK-1 antibody; LERK1 antibody; Ligand of eph related kinase 1 antibody; OTTHUMP00000033242 antibody; OTTHUMP00000033271 antibody; secreted form antibody; TNF alpha-induced protein 4 antibody; TNFAIP 4 antibody; TNFAIP4 antibody; Tumor necrosis factor alpha induced protein 4 antibody; Tumor necrosis factor alpha-induced protein 4 antibody |
| Host | Rabbit |
| Clonality | Polyclonal |
| Conjugate | Unconjugated |
| Immunogen | Recombinant human Ephrin-A1 protein (19-182AA) |
| Isotype | IgG |
| Target | EFNA1 |
| Reactivity | Human |
| Applications | ELISA, IHC |
| Form | Liquid |
| Diluent Buffer | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Uniprot | P20827 |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Background | Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis. |
| Supplier | Cusabio |
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