| Product Name | Efna1 Antibody, FITC conjugated |
|---|---|
| Description | Rabbit polyclonal antibody against Ephrin-A1 conjugated to FITC |
| Synonyms | Efna1 antibody; Epgl1 antibody; Lerk1 antibody; Ephrin-A1 antibody; EPH-related receptor tyrosine kinase ligand 1 antibody; LERK-1 antibody; Immediate early response protein B61) [Cleaved into: Ephrin-A1 antibody; secreted form] antibody |
| Host | Rabbit |
| Clonality | Polyclonal |
| Conjugate | FITC |
| Immunogen | Recombinant Rat Ephrin-A1 protein (18-182AA) |
| Isotype | IgG |
| Target | Efna1 |
| Reactivity | Rat |
| Applications | ELISA, Dot Blot |
| Form | Liquid |
| Diluent Buffer | Preservative: 0.03% Proclin 300Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Uniprot | P97553 |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Background | Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis By similarity. |
| Supplier | Cusabio |
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