| Product Name | EIF2AK1 Antibody, Biotin conjugated |
|---|---|
| Description | Rabbit polyclonal antibody against EIF2AK1 conjugated to Biotin. |
| Synonyms | E2AK1_HUMAN antibody; EC 2.7.11.1 antibody; Eif2ak1 antibody; Eukaryotic translation initiation factor 2 alpha kinase 1 antibody; Eukaryotic translation initiation factor 2-alpha kinase 1 antibody; HCR antibody; Heme controlled repressor antibody; Heme regulated eukaryotic initiation factor eIF 2 alpha kinase antibody; Heme regulated inhibitor antibody; Heme regulated initiation factor 2 alpha kinase antibody; Heme regulated repressor antibody; Heme sensitive initiation factor 2a kinase antibody; Heme-controlled repressor antibody; Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase antibody; Heme-regulated inhibitor antibody; Hemin sensitive initiation factor 2 alpha kinase antibody; Hemin-sensitive initiation factor 2-alpha kinase antibody; HRI antibody; KIAA1369 antibody; PRO1362 antibody |
| Host | Rabbit |
| Clonality | Polyclonal |
| Conjugate | Biotin |
| Immunogen | Recombinant Human Eukaryotic translation initiation factor 2-alpha kinase 1 protein (1-86AA) |
| Isotype | IgG |
| Target | EIF2AK1 |
| Reactivity | Human |
| Applications | ELISA |
| Form | Liquid |
| Diluent Buffer | Preservative: 0.03% Proclin 300Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Uniprot | Q9BQI3 |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Background | Inhibits protein synthesis at the translation initiation level, in response to various stress conditions, including oxidative stress, heme deficiency, osmotic shock and heat shock. Exerts its function through the phosphorylation of EIF2S1 at 'Ser-48' and 'Ser-51', thus preventing its recycling. Binds hemin forming a 1:1 complex through a cysteine thiolate and histidine nitrogenous coordination. This binding occurs with moderate affinity, allowing it to sense the heme concentration within the cell. Thanks to this unique heme-sensing capacity, plays a crucial role to shut off protein synthesis during acute heme-deficient conditions. In red blood cells (RBCs), controls hemoglobin synthesis ensuring a coordinated regulation of the synthesis of its heme and globin moieties. Thus plays an essential protective role for RBC survival in anemias of iron deficiency. Similarly, in hepatocytes, involved in heme-mediated translational control of CYP2B and CYP3A and possibly other hepatic P450 cytochromes. May also contain ER stress during acute heme-deficient conditions (By similarity). |
| Supplier | Cusabio |
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