| Product Name | EIF2S2 (Ab-67) Antibody |
|---|---|
| Description | Rabbit polyclonal antibody to EIF2S2 (Ab-67) |
| Synonyms | DKFZp686L18198 antibody; eIF 2 beta antibody; eIF-2-beta antibody; EIF2 antibody; EIF2B antibody; EIF2beta antibody; EIF2S2 antibody; Eukaryotic initiation factor 2 beta antibody; eukaryotic initiation factor 2-beta antibody; Eukaryotic translation initiation factor 2 beta antibody; Eukaryotic translation initiation factor 2 subunit 2 antibody; Eukaryotic translation initiation factor 2 subunit 2 beta 38kDa antibody; Eukaryotic translation initiation factor 2 subunit 2 beta antibody; Eukaryotic translation initiation factor 2 subunit beta antibody; eukaryotic translation initiation factor 2; subunit 2 beta; 38kDa antibody; IF2B_HUMAN antibody; MGC8508 antibody; PPP1R67 antibody; protein phosphatase 1; regulatory subunit 67 antibody |
| Host | Rabbit |
| Clonality | Polyclonal |
| Conjugate | Unconjugated |
| Immunogen | Synthesized peptide derived from N-terminal of human eIF2B. |
| Isotype | IgG |
| Target | EIF2S2 |
| Reactivity | Human, Mouse |
| Applications | ELISA, WB |
| Form | liquid |
| Diluent Buffer | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Uniprot | P20042 |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Background |
eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B. Pathak V.K., Cell 54:633-639(1988). Deloukas P., Nature 414:865-871(2001). Olsen J.V., Cell 127:635-648(2006). |
| Supplier | Cusabio |
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