| Product Name | Endomorphin-1 |
|---|---|
| Description |
Endomorphin 1 is an endogenous opioid peptide and one of the two endomorphins. Endomorphin 1 has exceptionally high affinity and selectivity for μ opioid receptors (4000- and 15000-fold preference over δ and κ respectively and may be the actual endogenous ligand of the μ-receptor. Endomorphin 1 is distributed throughout the human, rodent and primate central and peripheral nervous systems, and has a more potent analgesic effect in acute and neuropathic pain than other opiates such as morphine, with fewer side effects. |
| Synonyms | EM1 |
| Molecular Weight | 610.67 Da |
| Target | μ Opioid receptors |
| Amino Acid Sequence | YPWF-NH2 |
| Form | Freeze dried solid |
| Purity | >95% by hplc |
| Cas Number | 189388-22-5 |
| Storage | Store dry, frozen and in the dark |
| Notes | Modifications: C-terminal amide |
| References |
Zadina et al (1997) A potent and selective endogenous agonist for the μ-opiate receptor. Nature 386 499 PMID: 9087409Mehta et al (2001) Endomorphin-1: Induction of Motor Behavior and Lack of Receptor Desensitization. J. Neuroscience 21(12) 4436 PMID: 11404430Gu et al (2017) Endomorphins: Promising Endogenous Opioid Peptides for the Development of Novel Analgesics. Neurosignals 25 98 PMID: 29132133 Related areas All peptides >All μ opioid receptor modulators >All pain research categories > |
| Supplier | Isca Biochemicals Limited |
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