| Product Name | Endomorphin-2 |
|---|---|
| Description |
Endomorphin-2 is an endogenous peptide with extremely high affinity and selectivity for μ-opioid receptors, with Ki values of 0.69, 9233 and 5240 nM for μ, δ and κ receptors respectively. Endomorphin-2 is one of the two endomorphins and along with endomorphin-1 produces analgesia in animals, but whereas endomorphin-1 is more prevalent in the brain, endomorphin-2 is more prevalent in the spinal cord. |
| Synonyms | EM-2 |
| Molecular Weight | 571.65 Da |
| Target | μ Opioid receptors |
| Amino Acid Sequence | YPFF-NH2 |
| Form | Freeze dried solid |
| Purity | >95% by hplc |
| Cas Number | 141801-26-5 |
| Storage | Store dry, frozen and in the dark |
| Notes | Modifications: C-terminal amide |
| References |
Zadina et al (1997) A potent and selective endogenous agonist for the μ-opiate receptor. Nature 386 499 PMID: 9087409Okutsu et al (2006) Endomorphin-2 and Endomorphin-1 Promote the Extracellular Amount of Accumbal Dopamine via Nonopioid and Mu-Opioid Receptors, Respectively. Neuropsychopharmacology 31 375 PMID: 16034447Rivero et al (2012). Endomorphin-2: a biased agonist at the μ-opioid receptor. Molecular Pharmacology 82(2) 178 PMID: 22553358 Related areas All peptides >All μ opioid receptor modulators >All pain research categories > |
| Supplier | Isca Biochemicals Limited |
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