| Product Name | EPHB2 Antibody |
|---|---|
| Description | Rabbit polyclonal antibody to EPHB2 |
| Synonyms | cek5 antibody; Developmentally regulated EPH related tyrosine kinase antibody; DRT antibody; EK5 antibody; ELK related protein tyrosine kinase antibody; Eph receptor B2 antibody; EPH tyrosine kinase 3 antibody; EPH-like kinase 5 antibody; EPHB2 antibody; EPHB2_HUMAN antibody; Ephrin type B receptor 2 antibody; Ephrin type-B receptor 2 antibody; EPHT 3 antibody; ERK antibody; ETECK antibody; hEK5 antibody; Nuk antibody; Prkm 5 antibody; Receptor protein tyrosine kinase HEK 5 antibody; Renal carcinoma antigen NY-REN-47 antibody; Sek 3 antibody; Tyro 5 antibody; Tyrosine protein kinase receptor CEK 5 antibody; Tyrosine protein kinase receptor EPH 3 antibody; Tyrosine protein kinase receptor QEK 5 antibody; Tyrosine-protein kinase receptor EPH-3 antibody; Tyrosine-protein kinase TYRO5 antibody |
| Host | Rabbit |
| Clonality | Polyclonal |
| Conjugate | Unconjugated |
| Immunogen | Synthesized peptide derived from C-terminal of human EPHB2. |
| Isotype | IgG |
| Target | EPHB2 |
| Reactivity | Human |
| Applications | ELISA, WB |
| Form | liquid |
| Diluent Buffer | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Uniprot | P29323 |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Background |
Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Functions in axon guidance during development. Involved in the guidance of commissural axons, that form a major interhemispheric connection between the 2 temporal lobes of the cerebral cortex. Also involved in guidance of contralateral inner ear efferent growth cones at the midline and of retinal ganglion cell axons to the optic disk. Beside axon guidance, also regulates dendritic spines development and maturation and stimulates the formation of excitatory synapses. Upon activation by EFNB1, abolishes the ARHGEF15-mediated negative regulation on excitatory synapse formation. Controls other aspects of development including angiogenesis, palate development and in inner ear development through regulation of endolymph production. Forward and reverse signaling through the EFNB2/EPHB2 complex regulate movement and adhesion of cells that tubularize the urethra and septate the cloaca. May function as a tumor suppressor. Kiyokawa E., Cancer Res. 54:3645-3650(1994). Ikegaki N., Hum. Mol. Genet. 4:2033-2045(1995). Tang X.X., Oncogene 17:521-526(1998). |
| Supplier | Cusabio |
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