| Product Name | Ephb4, 16-539aa, Mouse, Baculovirus |
|---|---|
| Description | Ephb4, also known as ephrin type-B receptor 4 isoform b, is a member of the Eph receptor tyrosine kinase family shown to act in neuronal guidance and mediate venal/arterial separation. Ephb4 provides survival advantage to squamous cell carcinoma of the head and neck. It has tumor suppressor activities and that regulation of cell proliferation, extracellular matrix remodeling, and invasive potential are important mechanisms of tumor suppression. Recombinant mouse Ephb4, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques. |
| Synonyms | Ephrin type-B receptor 4 isoform b, Eph receptor B4, AI042935, Htk, MDK2, Myk1, Tyro11, Ephb4, EPHB4_HUMAN, Ephrin receptor, EphB4, Ephrin type-B receptor 4, Hepatoma Transmembrane Kinase, HTK, MYK 1, MYK1, TYRO 11, TYRO11, Tyrosine-protein kinase receptor HTK, Tyrosine-protein kinase TYRO11 |
| Host | Virus |
| Molecular Weight |
37.5kDa (326aa) 28-40kDa (SDS-PAGE under reducing conditions) |
| Amino Acid Sequence | LEETLLNTKL ETADLKWVTY PQAEGQWEEL SGLDEEQHSV RTYEVCDMKR PGGQAHWLRT GWVPRRGAVH VYATIRFTMM ECLSLPRASR SCKETFTVFY YESEADTATA HTPAWMENPY IKVDTVAAEH LTRKRPGAEA TGKVNIKTLR LGPLSKAGFY LAFQDQGACM ALLSLHLFYK KCSWLITNLT YFPETVPREL VVPVAGSCVA NAVPTANPSP SLYCREDGQW AEQQVTGCSC APGYEAAESN KVCRACGQGT FKPQIGDESC LPCPANSHSN NIGSPVCLCR IGYYRARSDP RSSPCTTPPS APRSVVHHLN GSTLRLEWSA PLESGGREDL TYAVRCRECR PGGSCLPCGG DMTFDPGPRD LVEPWVAIRG LRPDVTYTFE VAALNGVSTL ATGPPPFEPV NVTTDREVPP AVSDIRVTRS SPSSLILSWA IPRAPSGAVL DYEVKYHEKG AEGPSSVRFL KTSENRAELR GLKRGASYLV QVRARSEAGY GPFGQEHHSQ TQLDESESWR EQLAVEHHHH HH |
| Tag | His-tag |
| Form | Liquid, in Phosphate Buffered Saline (pH 7.4) containing 20% glycerol. |
| Concentration | 0.5mg/ml (determined by Absorbance at 280nm) |
| Purity | > 85% by SDS-PAGE. |
| Storage | Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -2°C or -7°C. Avoid repeated freezing and thawing cycles. |
| References | Xiao Z. et al., (2012) Cancer Biol Ther. 13:630-637. Masood R. et al., (2006) Int J Cancer. 119:1236-1248. Dopeso H. et al., (2009) Cancer Res. 69:7430-7438. |
| Background | Ephb4, also known as ephrin type-B receptor 4 isoform b, is a member of the Eph receptor tyrosine kinase family shown to act in neuronal guidance and mediate venal/arterial separation. Ephb4 provides survival advantage to squamous cell carcinoma of the head and neck. It has tumor suppressor activities and that regulation of cell proliferation, extracellular matrix remodeling, and invasive potential are important mechanisms of tumor suppression. Recombinant mouse Ephb4, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques. |
| Supplier | ARP |
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