| Product Name | ERBB2 Antibody |
|---|---|
| Description | Rabbit polyclonal antibody to HER2 |
| Synonyms | Verb b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog antibody; C erb B2/neu protein antibody; CD340 antibody; CD340 antigen antibody; Cerb B2/neu protein antibody; CerbB2 antibody; Erb b2 receptor tyrosine kinase 2 antibody; ErbB-2 proto-oncogene antibody; ERBB2 antibody; ERBB2_HUMAN antibody; HER 2 antibody; HER 2/NEU antibody; HER2 antibody; Herstatin antibody; Human epidermal growth factor receptor 2 antibody; Metastatic lymph node gene 19 protein antibody; MLN 19 antibody; MLN19 antibody; NEU antibody; NEU proto oncogene antibody; Neuro/glioblastoma derived oncogene homolog antibody; Neuroblastoma/glioblastoma derived oncogene homolog antibody; NGL antibody; p185erbB2 antibody; Proto-oncogene c-ErbB-2 antibody; Proto-oncogene Neu antibody; Receptor tyrosine-protein kinase erbB-2 antibody; TKR1 antibody; Tyrosine kinase type cell surface receptor HER2 antibody; Tyrosine kinase-type cell surface receptor HER2 antibody; V erb b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog) antibody; V erb b2 avian erythroblastic leukemia viral oncogene homolog 2 antibody; V erb b2 avian erythroblastic leukemia viral oncoprotein 2 antibody; V erb b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) antibody; V erb b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog antibody; Verb b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) antibody |
| Host | Rabbit |
| Clonality | Polyclonal |
| Conjugate | Unconjugated |
| Immunogen | A synthetic peptide of human ERBB2 |
| Isotype | IgG |
| Target | ERBB2 |
| Reactivity | Human, Mouse, Rat |
| Applications | ELISA, IHC, WB |
| Form | liquid |
| Diluent Buffer | Store at -20°C or -80°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Uniprot | P04626 |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Background | The ErbB2 (HER2) proto-oncogene encodes a 185 kDa transmembrane, receptor-like glycoprotein with intrinsic tyrosine kinase activity. While ErbB2 lacks an identified ligand, ErbB2 kinase activity can be activated in the absence of a ligand when overexpressed and through heteromeric associations with other ErbB family members. Amplification of the ErbB2 gene and overexpression of its product are detected in almost 40% of human breast cancers. Binding of the c-Cbl ubiquitin ligase to ErbB2 at Tyr1112 leads to ErbB2 poly-ubiquitination and enhances degradation of this kinase. ErbB2 is a key therapeutic target in the treatment of breast cancer and other carcinomas and targeting the regulation of ErbB2 degradation by the c-Cbl-regulated proteolytic pathway is one potential therapeutic strategy. Phosphorylation of the kinase domain residue Tyr877 of ErbB2 (homologous to Tyr416 of pp60c-Src) may be involved in regulating ErbB2 biological activity. The major autophosphorylation sites in ErbB2 are Tyr1248 and Tyr1221/1222; phosphorylation of these sites couples ErbB2 to the Ras-Raf-MAP kinase signal transduction pathway. |
| Supplier | Cusabio |
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