| Product Name | Exendin-4 (5-39) amide |
|---|---|
| Description | Exendin-4 (5-39) is an antagonist of glucagon-like peptide 1 (GLP-1) receptors. GLP-1 is a G protein-coupled receptor (GPCR) that shares sequence identity with other Family B receptors such as those for secretin, glucagon, and vasoactive intestinal peptide. Unlike the full length exendin-4, a GLP-1 agonist, exendin (5-39) antagonizes GLP-1 stimulated insulin release after food intake. Exendin (5-39) also modulates synaptic transmission via glutamate uptake in the dentate gyrus and improves memory impairment in β-amyloid protein-treated rats. |
| Synonyms | Exendin-4 (5-39), GH-009, GH009, GLP-1, H-TFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2, TFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2, antagonist of glucagon-like peptide 1 |
| Molecular Weight | 3806.2 Da |
| Target | Glucagon and related receptors |
| Amino Acid Sequence | TFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2 |
| Form | Freeze dried solid |
| Purity | >95% by HPLC |
| Storage | Store desiccated, frozen and in the dark |
| Notes | Modifications: C terminal amide |
| References |
Kobayashi et al (2013) Exendin (5-39), an antagonist of GLP-1 receptor, modulates synaptic transmission via glutamate uptake in the dentate gyrus. Brain Res. 1505 1 PMID: 23318256Liao et al (2015) In Vitro Metabolic Stability of Exendin-4: Pharmacokinetics and Identification of Cleavage Products. PLoS ONE 10(2) e0116805 PMID: 25723538 Related areas All peptides >All glucagon and related receptor modulators >All endocrinology research categories >All diabetes research categories >All neuroscience research categories > |
| Supplier | Isca Biochemicals Limited |
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