| Product Name | Exendin-4 (9-39) amide |
|---|---|
| Description | Exendin-4 (9-39) amide is a potent and selective glucagon-like peptide-1 (GLP-1) receptor antagonist with a Kd of 1.7 nM at cloned human GLP-1 receptors. Exendin-4 (9-39) amide inhibits cAMP production and insulin release caused by GLP-1 (7-36) and exendin-4. Exendin-4 (9-39) amide also blocks the inhibitory effect of GLP-1 on food intake in rats. |
| Synonyms | Exendin(9-39) amide, Avexitide, 9-39-Exendin 4 (Heloderma suspectum) |
| Molecular Weight | 3369.8 Da Da |
| Target | Glucagon and related receptors |
| Amino Acid Sequence | DLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2 |
| Form | Freeze dried solid |
| Purity | >95% by HPLC |
| Cas Number | 133514-43-9 |
| Storage | Store desiccated, frozen and in the dark |
| Notes | Modifications: C terminal amide |
| References |
Raufman et al (1991) Exendin-3, a novel peptide from the Heloderma horridum venom, interacts with vasoactive intestinal peptide receptors and a newly described receptor on dispersed acini from guinea pig pancreas. J.Biol.Chem. 266 2897 PMID: 1704369Goke et al (1993) Exendin-4 is a high potency agonist and truncated exendin-(9-39)-amide an antagonist at the glucagon-like peptide 1-(7-36)-amide receptor of Ins-Secr.g β-cells. J.Biol.Chem. 268 19650 PMID: 8396143Calabria et al (2012) GLP-1 receptor antagonist exendin-(9-39) elevates fasting blood glucose levels in congenital hyperinsulinism owing to inactivating mutations in the ATP-sensitive K+ channel. Diabetes 61(10) 2585 doi:10.2337/db12-0166 Related areas All peptides >All glucagon and related receptor modulators >All endocrinology research categories >All diabetes research categories > |
| Supplier | Isca Biochemicals Limited |
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