| Product Name | Exendin-4 |
|---|---|
| Description | Exendin-4, also known as exenatide, is a high affinity glucagon-like peptide 1 (GLP-1) receptor agonist originally isolated from Heloderma suspectum venom. It has 50% amino acid homology to GLP-1 and a longer half-life in vivo, and potentiates glucose-induced insulin secretion in isolated rat islets. Exenatide is used to treat type 2 diabetes mellitus as an add-on treatment and has also been evaluated for the treatment of Parkinson's disease. |
| Synonyms | Exenatide |
| Molecular Weight | 4186.6 Da |
| Target | Glucagon and related receptors |
| Amino Acid Sequence | HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2 |
| Form | Freeze dried solid |
| Purity | >95% by HPLC |
| Cas Number | 141758-74-9 |
| Storage | Store desiccated at -20°C in the dark |
| Notes | Modifications: C terminal amide |
| References |
Eng et al (1992) Isolation and characterization of exendin-4, an exendin-3 analogue, from Heloderma suspectum venom. J.Biol.Chem. 267 7402 PMID: 1313797Goke et al (1993) Exendin-4 is a high potency agonist and truncated exendin-(9-39)-amide an antagonist at the glucagon-like peptide 1-(7-36)-amide receptor of Ins-Secr.g β-cells. J.Biol.Chem. 268 19650 PMID: 8396143Varin et al (2016) Inhibition of the MAP3 kinase Tpl2 protects rodent and human β-cells from apoptosis and dysfunction induced by cytokines and enhances anti-inflammatory actions of exendin-4. Cell Death Dis. 7 e2065 https://doi.org/10.1038/cddis.2015.399 Related areasAll peptides >All glucagon and related receptor modulators >All endocrinology research categories >All diabetes research categories > |
| Supplier | Isca Biochemicals Limited |
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