| Product Name | EYA1 Antibody |
|---|---|
| Description | Rabbit polyclonal antibody to EYA1 |
| Synonyms | BOP antibody; BOR antibody; BOS1 antibody; EYA transcriptional coactivator and phosphatase 1 antibody; Eya1 antibody; EYA1_HUMAN antibody; Eyes absent 1 antibody; Eyes absent 1 homolog antibody; Eyes absent homolog 1 (Drosophila) antibody; Eyes absent homolog 1 antibody; Eyes absent homolog1 antibody; MGC141875 antibody; OFC1 antibody |
| Host | Rabbit |
| Clonality | Polyclonal |
| Conjugate | Unconjugated |
| Immunogen | Recombinant Human Eyes absent homolog 1 protein (168-321AA) |
| Isotype | IgG |
| Target | EYA1 |
| Reactivity | Human |
| Applications | ELISA, IF, IHC |
| Form | Liquid |
| Diluent Buffer | Preservative: 0.03% Proclin 300Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Uniprot | Q99502 |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Background | Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5 (By similarity). Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress (PubMed:19234442). Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis (By similarity). Has also phosphatase activity with proteins phosphorylated on Ser and Thr residues (in vitro) (By similarity). Required for normal embryonic development of the craniofacial and trunk skeleton, kidneys and ears (By similarity). Together with SIX1, it plays an important role in hypaxial muscle development; in this it is functionally redundant with EYA2 (By similarity). |
| Supplier | Cusabio |
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