| Product Name | F1 |
|---|---|
| Description |
F1 is a peptide derived from amino acids 46-60 of IkB kinase (IKK) interacting protein (IKIP) fused to a TAT cell penetrating peptide. F1 peptide specifically interacts with IKKalpha/beta to block association with the regulatory subunit NEMO, also known as IKKgamma, thereby inhibiting the phosphorylation of IKKalpha/beta and the activation of NF-kB. F1 reduces LPS induced acute inflammation and attenuates Zymosan-induced acute arthritis in mice. |
| Synonyms | F1 peptide, TAT-IKIP (46-60) |
| Molecular Weight | 3189.91 Da |
| Target | Nuclear receptor modulators,Protein-protein interactions,Kinases |
| Amino Acid Sequence | YGRKKRRQRRRLLSLAMTLGLAWLVF |
| Form | Freeze dried solid |
| Purity | >95% by hplc |
| Storage | Store dry, frozen and in the dark |
| Notes | Modifications: None |
| References |
Liu et al (2021) A Peptide Derived from IKK-Interacting Protein Attenuates NF-κ B Activation and Inflammation. J Immunol. Aug 23 ji2100397 Epub ahead of print PMID: 34426543 Related areasAll cell penetrating peptides >All nuclear receptor modulators >All protein-protein interaction modulators >All kinase modulators >All immunology categories > |
| Supplier | Isca Biochemicals Limited |
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