| Product Name | F9170 |
|---|---|
| Description |
F9170 is a peptide identified from the cytoplasmic region of the HIV-1 envelope glycoprotein (Env, gp120-gp41) which is able to inactivate HIV-1 virions and induce necrosis of HIV-1 infected cells. F9170 can enter the brain and lymph nodes and specifically targets the conserved cytoplasmic tail of HIV-1 Env to disrupt the integrity of the viral membrane. F9170 short term administration can control viral loads to below the limit of detection in chronically SHIV infected macaques. |
| Synonyms | AV-010, AV010, F 9170, F9170, GWEALKYLWNLLQYW |
| Molecular Weight | 1983.3 Da |
| Target | Antivirals |
| Amino Acid Sequence | GWEALKYLWNLLQYW |
| Form | Freeze dried solid |
| Purity | >95% by HPLC |
| Storage | Store dry, frozen and in the dark |
| Notes | Modifications: None |
| References |
Wang et al (2020) An amphipathic peptide targeting the gp41 cytoplasmic tail kills HIV-1 virions and infected cells. Sci Transl Med. 12(546):eaaz2254 PMID: 32493792 Related dataAll antivirals > |
| Supplier | Isca Biochemicals Limited |
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