| Product Name | Factor XII Monoclonal Antibody |
|---|---|
| Description | Factor XII (F XII,Hageman factor) is a 80kD,single chain glycoprotein that circulates in blood as an inactive zymogen. F XII plays an important role in blood coagulation,fibrinolysis,and kinin generation. When plasma comes into contact with negatively charged surfaces such as glass,kaolin,or dextran sulfate,F XII is bound to the surface and undergoes limited proteolysis by plasma kallikrein,resulting in two active enzyme forms,_-F XIIa and _-F XIIa. _-F XIIa consisting of a 28kD light chain containing the protease domain,and a 52kD heavy chain containing the anionic surface-binding domain. _-F XIIa consists of two disulfide-linked chains,a 2 kD light chain and a 28 kD heavy chain containing the catalytic domain. Defects in Factor XII do not cause any clinical symptoms and the sole effect is that whole-blood clotting time is prolonged. |
| Synonyms | Factor XII,Coagulation factor XII,F12,HAE3,HAEX,HAF,Hageman factor |
| Host | Mouse |
| Clone | 27 |
| Immunogen | Fusion protein of Factor XII |
| Isotype | IgG2b |
| Reactivity | Human |
| Applications | ELISA, IF, IHC, WB |
| Form | PBS with 0.02% sodium azide, 50% glycerol, PH7.3 |
| Uniprot | P00748 |
| Background | Factor XII (F XII,Hageman factor) is a 80kD,single chain glycoprotein that circulates in blood as an inactive zymogen. F XII plays an important role in blood coagulation,fibrinolysis,and kinin generation. When plasma comes into contact with negatively charged surfaces such as glass,kaolin,or dextran sulfate,F XII is bound to the surface and undergoes limited proteolysis by plasma kallikrein,resulting in two active enzyme forms,_-F XIIa and _-F XIIa. _-F XIIa consisting of a 28kD light chain containing the protease domain,and a 52kD heavy chain containing the anionic surface-binding domain. _-F XIIa consists of two disulfide-linked chains,a 2 kD light chain and a 28 kD heavy chain containing the catalytic domain. Defects in Factor XII do not cause any clinical symptoms and the sole effect is that whole-blood clotting time is prolonged. |
| Supplier | Elabscience |
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