| Product Name | Factor XIIIa Monoclonal Antibody |
|---|---|
| Description | Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion.Diseases associated with F13A1 include Factor Xiiia Deficiency and Factor Xiii Deficiency. Among its related pathways are Innate Immune System and Interleukin-4 and 13 signaling. Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. |
| Synonyms | Coagulation factor XIII A chain ,Coagulation factor XIIIa,Protein-glutamine gamma-glutamyltransferase A chain,Transglutaminase A chain |
| Host | Mouse |
| Clone | AS1A4 |
| Immunogen | Full length protein from eukaryotic expression system. |
| Isotype | IgG |
| Specificity | This antibody detects endogenous levels of Factor XIIIa |
| Reactivity | Human |
| Applications | IHC |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Uniprot | P00488 |
| Background |
Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion.Diseases associated with F13A1 include Factor Xiiia Deficiency and Factor Xiii Deficiency. Among its related pathways are Innate Immune System and Interleukin-4 and 13 signaling. Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. |
| Supplier | Elabscience |
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