| Product Name | FGFR3, 23-375aa, Human, Baculovirus |
|---|---|
| Description | FGFR3, also known as fibroblast growth factor receptor 3 isoform 1, is a member of the fibroblast growth factor receptor family. It is a family of polypeptide growth factors involved in a variety of activities including mitogenesis, angiogenesis, and wound healing. Its activation results in autophosphorylation of multiple tyrosine residues within the intracellular domain. It plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. It frequently involved in human developmental disorders and is associated with several cancers, including multiple myeloma (MM). Recombinant human FGFR3, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques. |
| Synonyms | Fibroblast growth factor receptor 3 isoform 1, FGFR3, ACH, CD333, CEK2, HSFGFR3EX, JTK4 |
| Host | Virus |
| Molecular Weight |
62.2kDa (561aa) 70-100kDa (SDS-PAGE under reducing conditions.) |
| Amino Acid Sequence | ESLGTEQRVV GRAAEVPGPE PGQQEQLVFG SGDAVELSCP PPGGGPMGPT VWVKDGTGLV PSERVLVGPQ RLQVLNASHE DSGAYSCRQR LTQRVLCHFS VRVTDAPSSG DDEDGEDEAE DTGVDTGAPY WTRPERMDKK LLAVPAANTV RFRCPAAGNP TPSISWLKNG REFRGEHRIG GIKLRHQQWS LVMESVVPSD RGNYTCVVEN KFGSIRQTYT LDVLERSPHR PILQAGLPAN QTAVLGSDVE FHCKVYSDAQ PHIQWLKHVE VNGSKVGPDG TPYVTVLKTA GANTTDKELE VLSLHNVTFE DAGEYTCLAG NSIGFSHHSA WLVVLPAEEE LVEADEAGSV YAGLEPKSCD KTHTCPPCPA PELLGGPSVF LFPPKPKDTL MISRTPEVTC VVVDVSHEDP EVKFNWYVDG VEVHNAKTKP REEQYNSTYR VVSVLTVLHQ DWLNGKEYKC KVSNKALPAP IEKTISKAKG QPREPQVYTL PPSRDELTKN QVSLTCLVKG FYPSDIAVEW ESNGQPENNY KTTPPVLDSD GSFFLYSKLT VDKSRWQQGN VFSCSVMHEA LHNHYTQKSL SLSPGKHHHH HH |
| Tag | hIgG-His-tag |
| Reactivity | Human |
| Applications | SDS-PAGE |
| Form | Liquid, in Phosphate Buffered Saline (pH 7.4) containing 10% glycerol. |
| Concentration | 0.5mg/ml (determined by Bradford assay) |
| Purity | > 95% by SDS-PAGE |
| Storage | Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -2°C or -7°C. Avoid repeated freezing and thawing cycles. |
| References | Keegan K., et al. (1991) Proc Natl Acad Sci U S A. 88:1095-1099. Castano-Betancourt MC., et al. (2016) PLoS Genet. 12:e1006260. |
| Background | FGFR3, also known as fibroblast growth factor receptor 3 isoform 1, is a member of the fibroblast growth factor receptor family. It is a family of polypeptide growth factors involved in a variety of activities including mitogenesis, angiogenesis, and wound healing. Its activation results in autophosphorylation of multiple tyrosine residues within the intracellular domain. It plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. It frequently involved in human developmental disorders and is associated with several cancers, including multiple myeloma (MM). Recombinant human FGFR3, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques. |
| Supplier | ARP |
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