Fibronectin leucine rich transmembrane protein 3, 29-528aa, Human, Baculovirus
| Product Name | Fibronectin leucine rich transmembrane protein 3, 29-528aa, Human, Baculovirus |
|---|---|
| Description | FLRT3, also known as leucine-rich repeat transmembrane protein FLRT3, belongs to the fibronectin leucine rich transmembrane protein (FLRT) family. It contains onefibronectin type-III domain and ten LRR(leucine-rich) repeats and expressed in kidney, brain, pancreas, skeletal muscle, lung, liver, placenta, and heart. The members of the FLRT family may have a function in cell adhesion and/or receptor signaling. It has been implicated in neurite outgrowth after nerve damage, as a positive regulator of FGF signalling and in homotypic cell adhesion. It may have a crucial role in regulating cellular adhesion between the epithelial apical ridge and the underlying mesenchyme and in establishing the dorso-ventral position of the ridge. Recombinant human FLRT3, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques. |
| Synonyms | FLRT3, HH21 |
| Host | Virus |
| Molecular Weight |
24.6kDa (230aa) 40-57kDa (SDS-PAGE under reducing conditions) |
| Amino Acid Sequence | KSCPSVCRCD AGFIYCNDRF LTSIPTGIPE DATTLYLQNN QINNAGIPSD LKNLLKVERI YLYHNSLDEF PTNLPKYVKE LHLQENNIRT ITYDSLSKIP YLEELHLDDN SVSAVSIEEG AFRDSNYLRL LFLSRNHLST IPWGLPRTIE ELRLDDNRIS TISSPSLQGL TSLKRLVLDG NLLNNHGLGD KVFFNLVNLT ELSLVRNSLT AAPVNLPGTN LRKLYLQDNH INRVPPNAFS YLRQLYRLDM SNNNLSNLPQ GIFDDLDNIT QLILRNNPWY CGCKMKWVRD WLQSLPVKVN VRGLMCQAPE KVRGMAIKDL NAELFDCKDS GIVSTIQITT AIPNTVYPAQ GQWPAPVTKQ PDIKNPKLTK DHQTTGSPSR KTITITVKSV TSDTIHISWK LALPMTALRL SWLKLGHSPA FGSITETIVT GERSEYLVTA LEPDSPYKVC MVPMETSNLY LFDETPVCIE TETAPLRMYN PTTTLNREQE KEPYKNPNLP LEHHHHHH |
| Tag | His-tag |
| Reactivity | Human |
| Applications | SDS-PAGE |
| Form | Liquid, in Phosphate Buffered Saline (pH 7.4) containing 10% glycerol. |
| Concentration | 1mg/ml (determined by Absorbance at 280nm) |
| Purity | > 90% by SDS-PAGE |
| Storage | Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -2°C or -7°C. Avoid repeated freezing and thawing cycles. |
| References | Lacy S E., et al. (1999) Genomics. 62:417-426. Haines B. P., et al. (2006) Dev. Biol. 297:14-25. |
| Background | FLRT3, also known as leucine-rich repeat transmembrane protein FLRT3, belongs to the fibronectin leucine rich transmembrane protein (FLRT) family. It contains onefibronectin type-III domain and ten LRR(leucine-rich) repeats and expressed in kidney, brain, pancreas, skeletal muscle, lung, liver, placenta, and heart. The members of the FLRT family may have a function in cell adhesion and/or receptor signaling. It has been implicated in neurite outgrowth after nerve damage, as a positive regulator of FGF signalling and in homotypic cell adhesion. It may have a crucial role in regulating cellular adhesion between the epithelial apical ridge and the underlying mesenchyme and in establishing the dorso-ventral position of the ridge. Recombinant human FLRT3, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques. |
| Supplier | ARP |
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