| Product Name | Fish Interleukin 1_ (IL- 1A) ELISA Kit |
|---|---|
| Description | IL-1_ is a member of interleukin 1 family. IL-1_ and IL-1_ recognize the same IL-1 receptor and share a number of similar biological functions. IL-1_ is predominantly a cell-associated molecule whereas IL-1_ is a secreted molecule.IL-1_ is synthesized primarily as a 31 kDa precursor that lacks a signal peptide. Cleavage of the precursor is via the cysteine protease calpain, resulting in a 17.5 kDa mature IL-1 molecule. Being active in the processed form, the IL-1 precursor is also biologically active via specific cell binding. A portion of the precursor is transported to the cell surface and associated with the cell membrane. Precursor IL-1_ can be released and cleaved by extracellular proteases when the cells die, and can also be cleaved by activation of the calcium-dependent, membrane-associated calpains. This assay has high sensitivity and excellent specificity for detection of Fish IL- 1A. No significant cross-reactivity or interference between Fish IL- 1A and analogues was observed. |
| Method | Sandwich ELISA |
| Detection Range | Request Information |
| Sensitivity | Request Information |
| Reactivity | Fish |
| Sample Types | Serum, Plasma, Other biological fluids. |
| Background | IL-1_ is a member of interleukin 1 family. IL-1_ and IL-1_ recognize the same IL-1 receptor and share a number of similar biological functions. IL-1_ is predominantly a cell-associated molecule whereas IL-1_ is a secreted molecule.IL-1_ is synthesized primarily as a 31 kDa precursor that lacks a signal peptide. Cleavage of the precursor is via the cysteine protease calpain, resulting in a 17.5 kDa mature IL-1 molecule. Being active in the processed form, the IL-1 precursor is also biologically active via specific cell binding. A portion of the precursor is transported to the cell surface and associated with the cell membrane. Precursor IL-1_ can be released and cleaved by extracellular proteases when the cells die, and can also be cleaved by activation of the calcium-dependent, membrane-associated calpains. |
| Supplier | Abebio |
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