| Product Name | Follistatin Monoclonal Antibody |
|---|---|
| Description | Follistatin (FST) is a member of the tissue growth factor _ family and is a secreted glycoprotein that antagonizes many members of the family,including activin A,growth differentiation factor11 ,and myostatin. It binds activin A with high affinity and whose expression can be induced by activin A and several other pro-inflammatory cytokines. Activin A-follistatin complexes are biologically inactive and bind to cell surface heparan sulphate-containing proteoglycans for internalisation and degradation. It has also been found to play a significant role in the management of skeletal muscle size and mass. It also has important roles in early embryonic development,differentiation of ovarian granulosa cells,liver fibrosis and polycystic ovarian syndrome. |
| Synonyms | Activin binding protein,follistatin,FS,FST |
| Host | Mouse |
| Clone | 1689 |
| Immunogen | Fusion protein of Follistatin |
| Isotype | IgG2b |
| Reactivity | Human, Mouse |
| Applications | ELISA, IF, IHC, WB |
| Form | PBS with 0.1% sodium azide, 50% glycerol, PH7.3 |
| Uniprot | P19883 |
| Background | Follistatin (FST) is a member of the tissue growth factor _ family and is a secreted glycoprotein that antagonizes many members of the family,including activin A,growth differentiation factor11 ,and myostatin. It binds activin A with high affinity and whose expression can be induced by activin A and several other pro-inflammatory cytokines. Activin A-follistatin complexes are biologically inactive and bind to cell surface heparan sulphate-containing proteoglycans for internalisation and degradation. It has also been found to play a significant role in the management of skeletal muscle size and mass. It also has important roles in early embryonic development,differentiation of ovarian granulosa cells,liver fibrosis and polycystic ovarian syndrome. |
| Supplier | Elabscience |
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