| Product Name | FOXA2 Antibody |
|---|---|
| Description | Rabbit polyclonal antibody to FOXA2 |
| Synonyms | Forkhead box A2 antibody; Forkhead box protein A2 antibody; FOX A2 antibody; foxa2 antibody; FOXA2_HUMAN antibody; Hepatic nuclear factor 3 beta antibody; Hepatocyte nuclear factor 3 antibody; Hepatocyte nuclear factor 3 beta antibody; Hepatocyte nuclear factor 3-beta antibody; HNF 3B antibody; HNF-3-beta antibody; HNF-3B antibody; HNF3B antibody; MGC19807 antibody; TCF 3B antibody; TCF-3B antibody; TCF3B antibody; Transcription factor 3B antibody |
| Host | Rabbit |
| Clonality | Polyclonal |
| Conjugate | Unconjugated |
| Immunogen | Peptide sequence around aa.435~439( A-S-P-L-A) derived from Human FoxA2(HNF3b). |
| Isotype | IgG |
| Target | FOXA2 |
| Reactivity | Human |
| Applications | ELISA, WB |
| Form | liquid |
| Diluent Buffer | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Uniprot | Q9Y261 |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Background |
Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' . In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally discribed as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation. Wolfrum C., Besser D., Luca E., Stoffel M. Proc. Natl. Acad. Sci. U.S.A. 100:11624-11629(2003) Motallebipour M., Ameur A., Reddy Bysani M.S. Genome Biol. 10:R129.0-R129.0(2009) Nock A., Ascano J.M., Jones T., Barrero M.J. J. Biol. Chem. 284:19915-19926(2009) |
| Supplier | Cusabio |
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