| Product Name | Foxy 5 |
|---|---|
| Description |
Foxy 5 is a formylated hexapeptide derived from the sequence of the Wnt5a ligand which acts as a Wnt5a mimetic. Foxy 5 is able to mimic important effects exerted by the full Wnt5a molecule such as binding to the Frz-5 receptor, and reproducing Wnt5a induced inhibition of human breast cancer cell migration in vitro. Foxy 5 significantly reduces the metastatic spread of WNT5a low DU145 prostate cancer cells in an in vivo orthotopic xenograft mouse model. |
| Synonyms | Wnt5a hexapeptide, Foxy5 |
| Molecular Weight | 694.77 Da |
| Target | Frizzled receptors |
| Amino Acid Sequence | N-Formyl-MDGCEL |
| Form | Freeze dried solid |
| Purity | >95% by hplc |
| Cas Number | 881188-51-8 |
| Storage | Store dry, frozen and in the dark |
| Notes | Modifications: N-Formylated |
| References |
Säfholm et al (2006) A formylated hexapeptide ligand mimics the ability of Wnt-5a to impair migration of human breast epithelial cells. J.Biol.Chem. 281 2740 PMID: 16330545Säfholm et al (2008) The Wnt-5a-derived hexapeptide Foxy-5 inhibits breast cancer metastasis in vivo by targeting cell motility. Clin.Cancer Res. 14 6556 PMID: 18927296Canesin (2017) Treatment with the WNT5A-mimicking peptide Foxy-5 effectively reduces the metastatic spread of WNT5A-low prostate cancer cells in an orthotopic mouse model. PLoS One 12(9) e0184418 PMID: 28886116 Related areasAll peptides >All frizzled receptor modulators >All cancer research categories >All stem cell research categories > |
| Supplier | Isca Biochemicals Limited |
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