| Product Name | FRS2 Monoclonal Antibody |
|---|---|
| Description | Fibroblast growth factor (FGF) receptor substrate 2 (FRS2) has an alternative name as SNT-1,it is an adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. FGF receptor substrates (FRS2 and FRS3) are key adaptor proteins that mediate FGF-FGFR signalling in benign as well as malignant tissue. FRS2 is a 508 amino-acid protein,which is phosphorylated on tyrosine residues. The molecular weight of non-phosphorylated FRS2 is 57-68 kDa,but phosphorylated FRS2 is 80-90 kDa. Phosphorylation of FRS2 is associated with activation of a number of MAP kinases. Allele-specific regulation of FGFR2 mRNA expression with a mildly increased breast cancer risk has been reported. |
| Synonyms | FGFR signaling adaptor SNT,FGFR substrate 2,FRS2,FRS2A,FRS2alpha,SNT,SNT 1,SNT1 |
| Host | Mouse |
| Clone | 19 |
| Immunogen | Fusion protein of FRS2 |
| Isotype | IgG3 |
| Reactivity | Human |
| Applications | ELISA, IF, IHC, WB |
| Form | PBS with 0.02% sodium azide, 50% glycerol, PH7.3 |
| Uniprot | Q8WU20 |
| Background | Fibroblast growth factor (FGF) receptor substrate 2 (FRS2) has an alternative name as SNT-1,it is an adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. FGF receptor substrates (FRS2 and FRS3) are key adaptor proteins that mediate FGF-FGFR signalling in benign as well as malignant tissue. FRS2 is a 508 amino-acid protein,which is phosphorylated on tyrosine residues. The molecular weight of non-phosphorylated FRS2 is 57-68 kDa,but phosphorylated FRS2 is 80-90 kDa. Phosphorylation of FRS2 is associated with activation of a number of MAP kinases. Allele-specific regulation of FGFR2 mRNA expression with a mildly increased breast cancer risk has been reported. |
| Supplier | Elabscience |
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