| Product Name | FSLLRY-NH2 |
|---|---|
| Description |
FSLLRY-NH2 is a selective PAR2 antagonist. PAR2 is associated with inflammation, metabolism, and disease and FSLLRY-NH2 is correspondingly active in a number of related disease models, it can reverse taxol induced mechanical allodynia, heat hyperalgesia and PKC activation in ICR mice, it blocks ERK activation and collagen production in isolated cardiac fibroblasts and reduces the level of pro-inflammatory genes IL-8, IL-1β, and TNF-α induced by H2O2 in HepG2 cells. FSLLRY-NH2 reduces symptoms in a mouse model of dermatophyte associated itch and is also effective in human asthma models. |
| Synonyms | 245329-02-6, FSLLRY-NH2, PR-080, PR080 |
| Molecular Weight | 796.97 Da |
| Target | Protease activated receptors |
| Amino Acid Sequence | FSLLRY-NH2 |
| Form | Freeze dried solid |
| Purity | >95% by hplc |
| Cas Number | 245329-02-6 |
| Storage | Store dry, frozen and in the dark |
| Notes | Modifications: C-terminal amide |
| References |
Andoh et al (2012) Involvement of serine protease and proteinase-activated receptor 2 in dermatophyte-associated itch in mice. J.Pharmacol.Exp.Ther. 343 91 PMID: 22761302Lee et al (2017) Inhibitory effect of FSLLRY-NH2 on inflammatory responses induced by hydrogen peroxide in HepG2 cells. Arch Pharm Res. 40(7):854 PMID: 28643288Ocasio-Rivera et al (2020) Targeting of protease activator receptor-2 (PAR-2) antagonist FSLLRY-NH2 as an asthma adjuvant therapy. Medicine (Baltimore) 99(43) e22351 PMID: 33120736 Related data All peptides >All protease activated receptors >All immunology research categories > |
| Supplier | Isca Biochemicals Limited |
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