| Product Name | Fz7-21 |
|---|---|
| Description |
Fz7-21 is a peptide identified from a phage library that impairs the function of Frizzled 7 (FZD7) in Wnt–β-catenin signalling, binding to the FZD7 extracellular cysteine rich domain (CRD) and altering its conformation and the architecture of its lipid-binding groove. Fz7-21 antagonises Wnt–β-catenin signaling in HEK293 cells stimulated with exogenous WNT3A with an IC50 of 100 nM and also blocks WNT3A-mediated stabilization of β -catenin in mouse L cells. FzD7-21 impairs stem cell function in intestinal organoids. |
| Synonyms | FZD7-binding peptide |
| Molecular Weight | 1796.05 Da |
| Target | Frizzled receptors |
| Amino Acid Sequence | Ac-LPSDDLEFWCHVMY-NH2 |
| Form | Freeze dried solid |
| Purity | >95% by hplc |
| Cas Number | 2247635-23-8 |
| Storage | Store dry, frozen and in the dark |
| Notes | Modifications: N terminal acetyl, C terminal amide |
| References |
Nile et al (2018) A selective peptide inhibitor of Frizzled 7 receptors disrupts intestinal stem cells. Nat Chem Biol. 14(6) 582 PMID: 29632413 Related dataAll peptides >All frizzled receptor modulators >All stem cell categories > |
| Supplier | Isca Biochemicals Limited |
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