| Product Name | FZD6 Antibody |
|---|---|
| Description | Rabbit polyclonal antibody to FZD6 |
| Synonyms | Frizzled 6 seven transmembrane spanning receptor antibody; Frizzled drosophila homolog of 6 antibody; Frizzled family receptor 6 antibody; Frizzled homolog 6 (Drosophila) antibody; Frizzled homolog 6 antibody; Frizzled-6 antibody; Frizzled6 antibody; Fz 6 antibody; Fz-6 antibody; Fz6 antibody; FZD 6 antibody; Fzd6 antibody; FZD6_HUMAN antibody; Hfz 6 antibody; hFz6 antibody; NDNC10 antibody |
| Host | Rabbit |
| Clonality | Polyclonal |
| Conjugate | Unconjugated |
| Immunogen | Synthetic peptide of human FZD6 |
| Isotype | IgG |
| Target | FZD6 |
| Reactivity | Human, Mouse |
| Applications | ELISA, IHC |
| Form | Liquid |
| Diluent Buffer | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Uniprot | O60353 |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Background | This gene represents a member of the 'frizzled' gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript variants, some of which do not encode a protein with a predicted signal peptide. |
| Supplier | Cusabio |
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