| Product Name | GAD2 Antibody |
|---|---|
| Description | Rabbit polyclonal antibody to GAD65 |
| Synonyms | Glutamate decarboxylase 2; EC 4.1.1.15; Glutamate decarboxylase 65 kDa isoform; GAD-65; 65 kDa glutamic acid decarboxylase |
| Host | Rabbit |
| Clonality | Polyclonal |
| Conjugate | Unconjugated |
| Immunogen | Synthesized peptide derived from human GAD1/GAD2. |
| Isotype | IgG |
| Target | GAD2 |
| Reactivity | Human, Mouse |
| Applications | ELISA, IHC, WB |
| Form | liquid |
| Diluent Buffer | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Uniprot | Q4G154 |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Background |
This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures. Alternative splicing of this gene results in two products, the predominant 67-kD form and a less-frequent 25-kD form. JB Travers, Chem Senses, Feb 2007; 32: 129 - 137. Rita Sulahian, Nucleic Acids Res., Mar 2006; 34: 1351 - 1357. Andrea Pillai, Development, Jan 2007; 134: 357 - 366. Dmytro P. Yevtushenko, J. Exp. Bot., Aug 2003; 54: 2001 - 2002. |
| Supplier | Cusabio |
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