| Product Name | Galectin-1, 1-135aa, Human, Recombinant |
|---|---|
| Description | Galectin-1 is a member of the beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. This protein is an autocrine negative growth factor that regulates cell proliferation. It controls cell survival by inducing apoptosis of activated T cells and immature thymocytes, thus Galectin-1 has immunosuppressive and anti-inflammatory properties. Galectin-1 also regulates tumor angiogenesis and is a target for angiostatic cancer therapy. Recombinant human Galectin-1 was expressed in E.coli and purified by using conventional chromatography |
| Synonyms | GAL1, GBP, LGALS1, S-Lac lectin1, galaptin, lactose-binding lectin 1, 14 kDa lectin, Beta galactoside binding lectin, Beta galactoside binding lectin L 14 I, DKFZp686E23103, Galectin, Galectin1, GBP, HBL, HPL, Lactose binding lectin 1, MAPK activating protein MP12, Lectin galactoside binding soluble 1, LGALS 1, Putative MAPK activating protein MP12, S Lac lectin 1. |
| Host | E. coli |
| Molecular Weight | 10.9 kDa (97aa), confirmed by MALDI-TOF. |
| Amino Acid Sequence | MACGLVASNL NLKPGECLRV RGEVAPDAKS FVLNLGKDSN NLCLHFNPRF NAHGDANTIV CNSKDGGAWG TEQREAVFPF QPGSVAEVCI TFDQANLTVK LPDGYEFKFP NRLNLEAINY MAADGDFKIK CVAFD |
| Reactivity | Human |
| Applications | SDS-PAGE |
| Form | Liquid, in Phosphate buffered saline (pH7.4) , 10% glycerol |
| Concentration | 0.5 mg/ml (determined by Bradford assay) |
| Purity | > 90% by SDS-PAGE |
| Storage | Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -2°C or -7°C. Avoid repeated freezing and thawing cycles. |
| References | Robert Kiss., et al. (2006). Glycobiology. 6(11):137R-157R Poirier F., et al. (2009). Dev Growth Differ. 51(7):607-15. |
| Background | Galectin-1 is a member of the beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. This protein is an autocrine negative growth factor that regulates cell proliferation. It controls cell survival by inducing apoptosis of activated T cells and immature thymocytes, thus Galectin-1 has immunosuppressive and anti-inflammatory properties. Galectin-1 also regulates tumor angiogenesis and is a target for angiostatic cancer therapy. Recombinant human Galectin-1 was expressed in E.coli and purified by using conventional chromatography |
| Supplier | ARP |
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