| Product Name | Gap 27 |
|---|---|
| Description |
Gap 27 is a connexin mimetic peptide corresponding to the SRPTEKTIFFI sequence (amino acids 204–214) on the second extracellular loop of connexin43 (Cx43) which is a selective and reversible inhibitor of Cx43 mediated cell–cell communication, which does not influence Cx43 expression levels. Gap27 effectively inhibits gap junction coupling at concentrations of 50 μM in keratinocytes and HeLa43 cells and is a versatile inhibitor of connexin mediated communication in tissue networks, having been used to identify the role of connexins in cardiomyocyte activities and in pathological processes such as epilepsy. |
| Synonyms | Connexin43 mimetic peptide, GAP 27, Connexin mimetic peptide, CMP |
| Molecular Weight | 1304.55 Da |
| Target | Gap junction channels |
| Amino Acid Sequence | SRPTEKTIFII |
| Form | Freeze dried solid |
| Purity | >95% by hplc |
| Cas Number | 198284-64-9 |
| Storage | Store dry, frozen and in the dark |
| Notes | Modifications: None |
| References |
Ko et al (2000) Biochemical and functional characterization of intercellular adhesion and gap junctions in fibroblasts. Am.J.Physiol.Cell Physiol. 279 C147 PMID: 10898726Pollok et al (2011), Connexin 43 mimetic peptide Gap27 reveals potential differences in the role of Cx43 in wound repair between diabetic and non€diabetic cells. J. Cellular Molecular Medicine 15 861 PMID: 20345849Faniku et al (2018) The Connexin Mimetic Peptide Gap27 and Cx43-Knockdown Reveal Differential Roles for Connexin43 in Wound Closure Events in Skin Model Systems. International J. Molecular Sciences 19(2) 604 PMID: 29463027 Related areas All peptides >All gap junction channel modulators >All immunology research categories > |
| Supplier | Isca Biochemicals Limited |
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