| Product Name | GH Polyclonal Antibody |
|---|---|
| Description | GH1 (Growth Hormone 1) is a Protein Coding gene. Diseases associated with GH1 include Growth Hormone Deficiency, Isolated, Type Ii and Kowarski Syndrome. Among its related pathways are GPCR Pathway and Phospholipase-C Pathway. GO annotations related to this gene include growth factor activity and growth hormone receptor binding. An important paralog of this gene is CSH1.The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed in the pituitary but not in placental tissue as is the case for the other four genes in the growth hormone locus. Mutations in or deletions of the gene lead to growth hormone deficiency and short stature. GH2 (Growth Hormone 2) is a Protein Coding gene. Diseases associated with GH2 include Choriocarcinoma and Prostate Carcinoma In Situ. Among its related pathways are GPCR Pathway and Phospholipase-C Pathway. GO annotations related to this gene include hormone activity. An important paralog of this gene is GH1.The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. As in the case of its pituitary counterpart, growth hormone 1, the predominant isoform of this particular family member shows similar somatogenic activity, with reduced lactogenic activity. Mutations in this gene lead to placental growth hormone/lactogen deficiency. |
| Synonyms | Somatotropin (Growth hormone) (GH) (GH-N) (Growth hormone 1) (Pituitary growth hormone) Growth hormone variant (GH-V) (Growth hormone 2) (Placenta-specific growth hormone) |
| Host | Rabbit |
| Immunogen | Synthetic peptide from human protein |
| Isotype | IgG |
| Reactivity | Human |
| Applications | ELISA, IHC |
| Form | PBS with 0.02% sodium azide and 50% glycerol pH 7.4. |
| Uniprot | P01241/P01242 |
| Background |
GH1 (Growth Hormone 1) is a Protein Coding gene. Diseases associated with GH1 include Growth Hormone Deficiency, Isolated, Type Ii and Kowarski Syndrome. Among its related pathways are GPCR Pathway and Phospholipase-C Pathway. GO annotations related to this gene include growth factor activity and growth hormone receptor binding. An important paralog of this gene is CSH1.The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed in the pituitary but not in placental tissue as is the case for the other four genes in the growth hormone locus. Mutations in or deletions of the gene lead to growth hormone deficiency and short stature. GH2 (Growth Hormone 2) is a Protein Coding gene. Diseases associated with GH2 include Choriocarcinoma and Prostate Carcinoma In Situ. Among its related pathways are GPCR Pathway and Phospholipase-C Pathway. GO annotations related to this gene include hormone activity. An important paralog of this gene is GH1.The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. As in the case of its pituitary counterpart, growth hormone 1, the predominant isoform of this particular family member shows similar somatogenic activity, with reduced lactogenic activity. Mutations in this gene lead to placental growth hormone/lactogen deficiency. |
| Supplier | Elabscience |
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