| Product Name | GIP (human) |
|---|---|
| Description | GIP (Gastric Inhibitory Polypeptide) is derived from a 153-amino acid proprotein encoded by the GIP gene and circulates as a biologically active 42-amino acid peptide. GIP is released by the K cells of the duodenum and jejunum in response to food intake and while it is weak inhibitor of gastric acid secretion, its main role is to stimulate insulin release. Type 2 diabetics are not responsive to GIP and have lower levels of GIP secretion after a meal when compared to non-diabetics. In mice, absence of GIP receptors correlates with resistance to obesity. |
| Synonyms | Gastric Inhibitory Polypeptide, Glucose dependent insulinotropic polypeptide |
| Molecular Weight | 4983.6 Da |
| Target | Glucagon and related receptors |
| Amino Acid Sequence | YAEGTFISDYSIAMDKIHQQDFVNWLLAQKGKKNDWKHNITQ |
| Form | Freeze dried solid |
| Purity | >95% by HPLC |
| Cas Number | 100040-31-1 |
| Storage | Store dessicated, dark and frozen |
| Notes | Modifications: None |
| References |
Wheeler et al (1995) Functional expression of the rat pancreatic islet glucose-dependent Insotropic polypeptide receptor: ligand binding and intracellular signaling properties. Endocrinol. 136 4629 PMID: 7664683Meier et al (2002) Gastric inhibitory polypeptide: the neglected incretin revisited. Regul.Peptides 107 1 PMID: 12137960Hansen et al (2016) N€terminally and C€terminally truncated forms of glucose€dependent insulinotropic polypeptide are high€affinity competitive antagonists of the human GIP receptor. Br. J. Pharmacol. 173 826 PMID: 26572091 Related areas All peptides >All glucagon and related receptor modulators >All endocrinology research categories >All diabetes research categories > |
| Supplier | Isca Biochemicals Limited |
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