| Product Name | Glucagon, human |
|---|---|
| Description | Recombinant human Glucagon (rHuGlucagon) is a single, non-glycosylated, polypeptide chain containing 29 amino acids and having a molecular mass of 3483 Dalton. Glucagon is beneficial for the culture of some cell types. It has been used in some biochemical regulation studies of glycogenolysis in hepatocytes. It has been also been found to induce DNA replication in primary cultures of adult rat hepatocytes when used in combinations with EGF and Insulin. Glucagon increases the blood glucose concentration by promoting rapid breakdown of liver glycogen, and also acts to relax smooth muscle such as the gastrointestinal tract. The sequence of the first five N-terminal amino acids was determined and was found to be His-Ser-Gln-Gly-Thr. |
| Synonyms | Formiminotransferase-cyclodeaminase, FTCD, LCHC1, LC-1 |
| Molecular Weight | 3483 Dalton |
| Biological Activity | The activity is determined by comparing, under certain conditions, the hyperglycemic effect it produces with that produced by the international standard or by reference preparation calibrated in IU and is found to be 1IU/mg |
| Form | Purified, in 49mgs of lactose solution |
| Concentration | 1 mg/ml |
| Purity | > 98%, as determined by: (a) Analysis by RP-HPLC (b) Analysis by SDS-PAGE |
| Storage | -2°C (aliquot), avoid repeated freeze and thaw cycles |
| Supplier | ARP |
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