| Product Name | Glucagon Like Peptide-1 (GLP-1), human |
|---|---|
| Description | Recombinant human Glucagon Like Peptide-1 (GLP-1) is a single, non-glycosylated, polypeptide chain containing 30 amino acids and having a molecular mass of 3298.7 Dalton. GLP-1 is a incretion hormone, which has been shown to stimulate secretion of insulin in the presence of elevated blood glucose concentrations, but not during periods of low blood glucose concentrations (hypoglycemia). GLP-1 is released from gut endocrine cells in response to nutrient ingestion. The hormone is a physiologic mediator of satiety and regulates energy absorption and disposal. GLP-1 is an insulinotropic hormone that has the ability to render pancreatic beta cells glucose-competent. It has been used in the therapy of type-2 diabetes. GLP-1 has activities of cyokines, although it is not classified as such due its small size GLP-1 enhances cell differentiation, plays a role in tissue regeneration, and mediates cytoprotection. The sequence of the first five N-terminal amino acids was determined and was found to be His-Ala-Glu-Gly-Thr. |
| Molecular Weight | 3298.7Dalton |
| Biological Activity | Regulates Glucose levels rapidly, Reduces Insulin resistance, Reduces Glucagon, Reduces HbA1c, Stimulates beta cell grwoth which stimulates insulin production |
| Form | Purified, in 49mgs of lactose solution |
| Concentration | 0.5 mg/ml |
| Purity | > 98%, as determined by: (a) Analysis by RP-HPLC (b) Analysis by SDS-PAGE |
| Storage | -2°C (aliquot), avoid repeated freeze and thaw cycles |
| Supplier | ARP |
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