| Product Name | Goat Interleukin 12 (IL-12/P40) ELISA Kit |
|---|---|
| Description | Interleukin 12 (IL-12) is an interleukin that is naturally produced by dendritic cells, macrophages and human B-lymphoblastoid cells (NC-37) in response to antigenic stimulation. IL-12 is involved in the differentiation of naive T cells into Th0 cells which will further develop into either Th1 cells or Th2 cells. It is known as a T cell stimulating factor, which can stimulate the growth and function of T cells. It stimulates the production of interferon-gamma (IFN-_) and tumor necrosis factor-alpha (TNF-_) from T and natural killer (NK) cells, and reduces IL-4 mediated suppression of IFN-_. T cells which produce IL-12 have a coreceptor, CD30, which is associated with IL-12 activity.IL-12 plays an important role in the activities of natural killer cells and T lymphocytes. IL-12 mediates enhancement of the cytotoxic activity of NK cells and CD8+ cytotoxic T lymphocytes. This assay has high sensitivity and excellent specificity for detection of Goat IL12B. No significant cross-reactivity or interference between Goat IL12B and analogues was observed. |
| Synonyms | CLMF, CLMF2, IL-12B, NKSF, NKSF2, IL12, subunit p40|interleukin 12, p40|interleukin 12B|interleukin-12 beta chain|natural killer cell stimulatory factor, 40 kD subunit |
| Method | Sandwich ELISA |
| Detection Range | Request Information |
| Sensitivity | Request Information |
| Reactivity | Goat |
| Sample Types | Serum, Plasma, Other biological fluids. |
| Background | Interleukin 12 (IL-12) is an interleukin that is naturally produced by dendritic cells, macrophages and human B-lymphoblastoid cells (NC-37) in response to antigenic stimulation. IL-12 is involved in the differentiation of naive T cells into Th0 cells which will further develop into either Th1 cells or Th2 cells. It is known as a T cell stimulating factor, which can stimulate the growth and function of T cells. It stimulates the production of interferon-gamma (IFN-_) and tumor necrosis factor-alpha (TNF-_) from T and natural killer (NK) cells, and reduces IL-4 mediated suppression of IFN-_. T cells which produce IL-12 have a coreceptor, CD30, which is associated with IL-12 activity.IL-12 plays an important role in the activities of natural killer cells and T lymphocytes. IL-12 mediates enhancement of the cytotoxic activity of NK cells and CD8+ cytotoxic T lymphocytes. |
| Supplier | Abebio |
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