GOPC, 278-454aa, Human

Proteins, Recombinant
More Information
Product Name GOPC, 278-454aa, Human
Background GOPC, also known as PIST, is a PDZ domain-containing Golgi protein. This protein functions as a homooligomer that interacts with a variety of proteins and plays a role in intracellular protein trafficking and degradation. Additionally, GOPC is thought to regulate ionic currents via membrane channel modification and may also play a role in autophagy. Chromosomal aberrations in the gene encoding GOPC are found in glioblastoma multiform (GBM), a common and aggressive form of brain tumor, suggesting a role for mutated PIST in carcinogenesis. Recombinant GOPC protein was expressed in E.coli and purified by using conventional chromatography techniques.
Species Human
Synonyms CAL, dJ94G16.2, FIG, GOPC1, PIST, Golgi-associated PDZ and coiled-coil motif-containing protein CFTR associated ligand, dJ94G16.2, FIG Fused in glioblastoma, Golgi associated PDZ and coiled coil motif containing, Golgi associated PDZ and coiled coil motif containing protein, GOPC 1, OTTHUMP00000040403, PDZ protein interacting specifically with TC 10, PDZ protein interacting specifically with TC10, PDZ/coiled coil domain binding partner for the rho family GTPase TC 10, PDZ/coiled coil domain binding partner for the rho family GTPase TC10, Protein interacting specifically with Tc 10, Protein interacting specifically with Tc10.
Host E.coli
Tag His-tag
Molecular Weight 16.6kDa (152aa), confirmed by MALDI-TOF.
Form Liquid, in 20mM Tris-HCl buffer (pH8.0) containing 50% glycerol, 2mM DTT
Concentration 0.25 mg/ml (determined by Bradford assay)
Purity > 90% by SDS-PAGE
Applications SDS-PAGE
NCBI NP_001017408
Storage Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Intended Use For Research Use Only
References Cheng J., et al. (2002) J Biol Chem. 277(5):3520-9.
Yao R., et al. (2001) Biochem Biophys Res Commun. 286(4):771-8.

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