| Product Name | GPS2 Polyclonal Antibody |
|---|---|
| Description | This gene encodes a protein involved in G protein-mitogen-activated protein kinase (MAPK) signaling cascades. When overexpressed in mammalian cells, this gene could potently suppress a RAS- and MAPK-mediated signal and interfere with JNK activity, suggesting that the function of this gene may be signal repression. The encoded protein is an integral subunit of the NCOR1-HDAC3 (nuclear receptor corepressor 1-histone deacetylase 3) complex, and it was shown that the complex inhibits JNK activation through this subunit and thus could potentially provide an alternative mechanism for hormone-mediated antagonism of AP1 (activator protein 1) function.GPS2 (G Protein Pathway Suppressor 2) is a Protein Coding gene. Diseases associated with GPS2 include Timothy Grass Allergy. Among its related pathways are HTLV-I infection and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. GO annotations related to this gene include transcription corepressor activity and GTPase inhibitor activity. |
| Synonyms | GPS2; G protein pathway suppressor 2; GPS-2 |
| Host | Rabbit |
| Immunogen | Synthesized peptide derived from the N-terminal region of human GPS2 |
| Isotype | IgG |
| Reactivity | Human, Mouse, Rat |
| Applications | ELISA, WB |
| Form | PBS with 0.02% sodium azide,0.5% BSA and 50% glycerol pH 7.4. |
| Uniprot | Q13227 |
| Background | This gene encodes a protein involved in G protein-mitogen-activated protein kinase (MAPK) signaling cascades. When overexpressed in mammalian cells, this gene could potently suppress a RAS- and MAPK-mediated signal and interfere with JNK activity, suggesting that the function of this gene may be signal repression. The encoded protein is an integral subunit of the NCOR1-HDAC3 (nuclear receptor corepressor 1-histone deacetylase 3) complex, and it was shown that the complex inhibits JNK activation through this subunit and thus could potentially provide an alternative mechanism for hormone-mediated antagonism of AP1 (activator protein 1) function.GPS2 (G Protein Pathway Suppressor 2) is a Protein Coding gene. Diseases associated with GPS2 include Timothy Grass Allergy. Among its related pathways are HTLV-I infection and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. GO annotations related to this gene include transcription corepressor activity and GTPase inhibitor activity. |
| Supplier | Elabscience |
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