| Product Name | GRIA3 Antibody |
|---|---|
| Description | Rabbit polyclonal antibody to GRIA3 |
| Synonyms | AMPA 3 antibody; AMPA selective glutamate receptor 3 antibody; AMPA-selective glutamate receptor 3 antibody; dJ1171F9.1 antibody; GluA3 antibody; GLUK3 antibody; GluR 3 antibody; GLUR C antibody; GLUR K3 antibody; GluR-3 antibody; GluR-C antibody; GluR-K3 antibody; GLUR3 antibody; GLURC antibody; Glutamate ionotropic receptor AMPA type subunit 3 antibody; Glutamate receptor 3 antibody; Glutamate receptor C antibody; Glutamate receptor ionotrophic AMPA 3 antibody; Glutamate receptor ionotropic antibody; Glutamate receptor subunit 3 antibody; Glutamate receptor; ionotropic; AMPA 3 antibody; GRIA 3 antibody; Gria3 antibody; GRIA3_HUMAN antibody; Ionotrophic Glutamate Receptor antibody; MRX94 antibody |
| Host | Rabbit |
| Clonality | Polyclonal |
| Conjugate | Unconjugated |
| Immunogen | Recombinant protein of human GRIA3 |
| Isotype | IgG |
| Target | GRIA3 |
| Reactivity | Human, Mouse, Rat |
| Applications | ELISA, IHC, WB |
| Form | liquid |
| Diluent Buffer | Store at -20°C or -80°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Uniprot | P42263 |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Background | AMPA- (_-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid), kainite- and NMDA- (N-methyl-D-aspartate) receptors are the three main families of ionotropic glutamate-gated ion channels. AMPA receptors (AMPARs) are comprised of four subunits (GluR 1-4) that assemble as homo- or hetero-tetramers and mediate the majority of fast excitatory transmissions in the CNS. AMPARs are implicated in synapse formation, stabilization and plasticity. Post-transcriptional modifications (alternative splicing and nuclear RNA editing) and post-translational modifications (glycosylation, phoshorylation) result in a very large number of permutations, fine-tuning the kinetic properties of AMPARs. GluR 3 knockout mice exhibited normal basal synaptic transmission and long-term depression (LTD) but enhanced long-term potentiation (LTP). In contrast, GluR 2/3 double knockout mice are impaired in basal synaptic transmission. Aberrant GluR 3 expression or activity is implicated in a number of diseases, including autoimmune epilepsy, X-linked mental retardation, Retts syndrome, amyotrophic lateral sclerosis and Alzheimer disease. |
| Supplier | Cusabio |
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