| Product Name | GRO/CINC-1, Rat, ELISA Kit |
|---|---|
| Description | Cytokine-induced neutrophil chemoattractant-1 (CINC-1) was originally purified from media conditioned by IL-1b stimulated rat kidney epithelioid cells (NRK-52E). Watanabe's group at Toyama Medical and Pharmaceutical University identified amino acid sequence that encodes for rat CINC-1 in 1989. CINC-1 is a member ofthe alpha (CXC) subfamily of chemokines. Three additional rat CXC chemokines (CINC-2a, CINC-2b, CINC-3/MIP-2) have been identified. The protein sequence of CINC-1 is 63 - 67% identical to that of CINC-2a, CINC-2b, CINC-3/MIP-2. In addition, GROa, GROb and GROy is sharing 68%, 71% and 69%, identity with CINC-1. This has been suggested that CINCs are the rat counterpart of human GROs. This kit is a solid phase sandwich ELISA using 2 kinds of high specific antibodies. Tetra Methyl Benzidine (TMB) is used as coloring agent (Chromogen). The strength of coloring is in proportion to the quantities of Rat GRO/ CINC-1. |
| Reactivity | Rat |
| Background | Cytokine-induced neutrophil chemoattractant-1 (CINC-1) was originally purified from media conditioned by IL-1b stimulated rat kidney epithelioid cells (NRK-52E). Watanabe's group at Toyama Medical and Pharmaceutical University identified amino acid sequence that encodes for rat CINC-1 in 1989. CINC-1 is a member ofthe alpha (CXC) subfamily of chemokines. Three additional rat CXC chemokines (CINC-2a, CINC-2b, CINC-3/MIP-2) have been identified. The protein sequence of CINC-1 is 63 - 67% identical to that of CINC-2a, CINC-2b, CINC-3/MIP-2. In addition, GROa, GROb and GROy is sharing 68%, 71% and 69%, identity with CINC-1. This has been suggested that CINCs are the rat counterpart of human GROs. |
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