| Product Name | GSK3A/GSK3B (Ab-279/216) Antibody |
|---|---|
| Description | Rabbit polyclonal antibody to GSK3A (Ab-279/216) |
| Synonyms | Factor A; GSK-3 alpha/beta; kinase GSK3-alpha/beta |
| Host | Rabbit |
| Clonality | Polyclonal |
| Conjugate | Unconjugated |
| Immunogen | Peptide sequence around aa.277~281/214~218 (V-S-Y-I-C) derived from Human GSK3 / . |
| Isotype | IgG |
| Target | GSK3A/GSK3B |
| Reactivity | Human, Mouse, Rat |
| Applications | ELISA, WB |
| Form | liquid |
| Diluent Buffer | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Uniprot | P49840/P49841 |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Background |
Participates in the Wnt signaling pathway. Implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates MUC1 in breast cancer cells, and decreases the interaction of MUC1 with CTNNB1/beta-catenin. Phosphorylates CTNNB1/beta-catenin. |
| Supplier | Cusabio |
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