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|Product Name||GSTM1, 1-181aa Human|
|Amino Acid Sequence||MGSSHHHHHH SSGLVPRGSH RSMPMILGYW DIRGLAHAIR LLLEYTDSSY EEKKYTMGDA PDYDRSQWLN EKFKLGLDFP NLPYLIDGAH KITQSNAILC YIARKHNLCG ETEEEKIRVD ILENQTMDNH MQLGMICYNP EFEKLKPKYL EELPEKLKLY SEFLGKRPWF AGNKGLEKIS AYMKSSRFLP RPVFSKMAVW GNK|
|Background||Glutathione S-transferase mu 1 isoform 2, also known as GSTM1, is a glutathione S-transferase that belongs to the mu class. GSTs (glutathione S-transferase) are differentially expressed in lung, liver and kidney tissue and, notably, three isoforms (GSTA1-1, GSTA1-4 and GSTM1) localize to the mitochondria in addition to the cytoplasm. The GSTM1 of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. Recombinant human GSTM1 protein, fused to His-tag at N-terminus, was expressed in E.coli.|
|Concentration||1mg/ml (determined by Bradford assay)|
|Form||Liquid, in 20mM Tris-HCl buffer (pH8.0) containing 10% glycerol 0.4M Urea|
|Intended Use||For Research Use Only|
|Molecular Weight||33.8 kDa(297aa)|
|NCBI Accession #||NP_666533|
|Purity||> 85% by SDS-PAGE|
|References||Bartley P A., et al. (2003) Oncogene. 22:7570-7575.
Moretti M., et al. (2007) BMC Public Health. 7:270.
|Storage||Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.|
|Synonyms||Glutathione S-transferase mu 1, GST1, GSTM1-1, GSTM1a-1a, GSTM1b-1b, GTH4, GTM1, H-B, MU, MU-1|
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