GUK1, 1-197aa, Human

Proteins, Recombinant
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Product Name GUK1, 1-197aa, Human
Applications SDS-PAGE
Background GUK1, also known as GMK, belongs to the guanylate kinase family. This protein exists as a monomer that catalyzes the ATP-dependent conversion of GMP to GDP, thereby playing an essential role in the recycling of GMP. Via its catalytic activity, GUK1 is thought to participate in regulating the supply of guanine nucleotides to signal transduction pathways. Overexpression of GUK1 is associated with pituitary adenocarcinomas, suggesting that GUK1 is involved in tumorigenesis. Recombinant human GUK1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
Concentration 0.5 mg/ml (determined by Bradford assay)
Form Liquid, in 20 mM Tris-HCl buffer (pH8.0) containing 0.1M Nacl, 1mM DTT, 10% glycerol
Species Human
Host E.coli
Intended Use For Research Use Only
Molecular Weight 85.2 kDa (732aa), confirmed by MALDI-TOF
NCBI Accession # NP_000849
Purity > 90 % by SDS-PAGE
References Da Rocha AA., et al. (2006) Pituitary. 9(2):83-92.
Brady WA., et al. (1996) J Biol Chem. 271(28):16734-40.
Storage Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Synonyms GMK, GMP kinase, Guanylate kinase

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