| Product Name | HDAC5 (Ab-498) Antibody |
|---|---|
| Description | Rabbit polyclonal antibody to HDAC5 (Ab-498) |
| Synonyms | Antigen NY CO 9 antibody; Antigen NY-CO-9 antibody; HD5 antibody; HDAC 5 antibody; HDAC5 antibody; HDAC5_HUMAN antibody; Histone deacetylase 5 antibody; NY CO 9 antibody |
| Host | Rabbit |
| Clonality | Polyclonal |
| Conjugate | Unconjugated |
| Immunogen | Peptide sequence around aa.496~500 (T-Q-S-S-P) derived from Human HDAC5/7. |
| Isotype | IgG |
| Target | HDAC5 |
| Reactivity | Human, Mouse, Rat |
| Applications | ELISA, IHC, WB |
| Form | liquid |
| Diluent Buffer | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Uniprot | Q9UQL6 |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Background |
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by HDAC5 belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene. |
| Supplier | Cusabio |
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