| Product Name | HDGF, 1-100aa, Human |
|---|---|
| Description | Hepatoma-derived growth factor isoform a, also known as HDGF, belongs to the hepatoma-derived growth factor family. HDGF was originally identified as a secreted mitogen from the human hepatoma cell line Huh-7. This nuclear targeted vascular smooth muscle cell mitogen is a heparin-binding protein that is highly expressed in tumor cells where it stimulates proliferation. HDGF is also reported to be involved in organ development and lung remodeling after injury by promoting proliferation of lung epithelial cells. Recombinant human HDGF was expressed in E.coli and purified by using conventional chromatography techniques. |
| Synonyms | HMG1L2, Hepatoma-derived growth factor isoform a Hepatoma derived growth factor, High mobility group protein 1 like 2, |
| Host | E. coli |
| Molecular Weight | 10.3 kDa (90aa), confirmed by MALDI-TOF. |
| Amino Acid Sequence | MSRSNRQKEY KCGDLVFAKM KGYPHWPARI DEMPEAAVKS TANKYQVFFF GTHETAFLGP KDLFPYEESK EKFGKPNKRK GFSEGLWEIE NNPTVKASGY |
| Tag | His-tag |
| Reactivity | Human |
| Applications | SDS-PAGE |
| Form | Liquid, in phosphate-buffered Saline (PBS) pH 7.4, 10% glycerol |
| Concentration | 0.5 mg/ml (determined by Bradford assay) |
| Purity | > 95% by SDS-PAGE |
| Storage | Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -2°C or -7°C. Avoid repeated freezing and thawing cycles. |
| References | Everett AD., et al. (2003) Curr Drug Tarqets. 4(5):367-71. Everett AD., et al. (2004) Am J Physiol Lung Cell Mol Physiol. 28(6):L1194-201. |
| Background | Hepatoma-derived growth factor isoform a, also known as HDGF, belongs to the hepatoma-derived growth factor family. HDGF was originally identified as a secreted mitogen from the human hepatoma cell line Huh-7. This nuclear targeted vascular smooth muscle cell mitogen is a heparin-binding protein that is highly expressed in tumor cells where it stimulates proliferation. HDGF is also reported to be involved in organ development and lung remodeling after injury by promoting proliferation of lung epithelial cells. Recombinant human HDGF was expressed in E.coli and purified by using conventional chromatography techniques. |
| Supplier | ARP |
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