| Product Name | α-helical CRF (9-41) |
|---|---|
| Description |
α-helical CRF (9-41) is a corticotropin releasing factor receptor (CRF) antagonist with Ki values of 17, 5 and 0.97 nM at human CRF1, rat CRF2α and mouse CRF2β receptors respectively. α-helical CRF (9-41) decreases anxiety like behaviour in the conditioned fear test and reverses the potentiation of startle amplitude produced by administration of CRF in anxiety models. α-helical CRF (9-41) pre-treatment blocks CRF induced food intake inhibition. |
| Synonyms | α-helical-Corticotropin-Releasing Factor 9-41, AHCRF, ah-CRF(9-41) |
| Molecular Weight | 3827 Da |
| Target | Corticotropin releasing factor receptors |
| Amino Acid Sequence | DLTFHLLREMLEMAKAEQEAEQAALNRLLLEEA-NH2 |
| Form | Freeze dried solid |
| Purity | >95% by hplc |
| Cas Number | 90880-23-2 |
| Storage | Store dry, frozen and in the dark |
| Notes | Modifications: C-terminal amide |
| References |
Swerdlow et al (1989) Potentiation of acoustic startle by corticotropin-releasing factor (CRF) and by fear are both reversed by α-helical CRF (9-41). Neuropsychopharmacology 2 285 PMID: 2610824Skórzewska et al (2009). The effect of CRF and α-helical CRF(9-41) on rat fear responses and amino acids release in the central nucleus of the amygdala. Neuropharmacology 57(2) 148 PMID: 19477189Smedh et al (2019) Pretreatment with a CRF antagonist amplifies feeding inhibition induced by fourth ventricular cocaine- and amphetamine-regulated transcript peptide. BMC Neurosci 20 11 PMID: 30885137 Related areas All peptides >All corticotropin releasing factor receptor modulators >All endocrinology categories >All neuroscience categories >All appetite regulation categories > |
| Supplier | Isca Biochemicals Limited |
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