| Product Name | Hexa-D-arginine |
|---|---|
| Description |
Hexa-D-arginine is an inhibitor of furin, with Ki values of 106 nM, 580 nM and 13.2 μM for furin, PACE4 and PC1 respectively. Pseudomonas aeruginosa exotoxin A (PEA) protein requires furin-mediated cleavage for manifestation of toxicity and hexa-d-arginine effectively blocks PEA-induced cell lysis and is itself noncytotoxic. Administration of hexa-d-arginine to PEA-treated mice significantly improves their survival rate and decreases circulating levels of tumour necrosis factor alpha. Hexa-D-arginine also blocks furin mediated SARS-CoV-2 spike protein cleavage to suppress virus production and cytopathic effects. |
| Synonyms | Hexa-d-arginine amide, D6R, Furin Inhibitor II |
| Molecular Weight | 954.16 Da |
| Target | Serine proteases,Furin |
| Amino Acid Sequence | rrrrrr-NH2 |
| Form | Freeze dried solid |
| Purity | >95% by hplc |
| Cas Number | 673202-67-0 |
| Storage | Store dry, frozen and in the dark |
| Notes | Modifications: C-terminal amide, arginines 1,2,3,4,5 and 6 are all D- configuration |
| References |
Cameron et al (2000) Polyarginines are potent furin inhibitors. J.Biol.Chem. 275 36741 PMID: 10958789Sarac et al (2002) The furin inhibitor hexa-D-arginine blocks the activation of Pseudomonas aeruginosa exotoxin A in vivo. Infect Immun. 70(12) 7136 PMID: 12438396Cheng et al (2020) Furin Inhibitors Block SARS-CoV-2 Spike Protein Cleavage to Suppress Virus Production and Cytopathic Effects. Cell Rep. 33(2) 108254 PMID: 33007239PubChem: Hexa-D-arginine Related areasAll peptides >All furin modulators >All antiviral agents >All immunology research categories > |
| Supplier | Isca Biochemicals Limited |
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