| Product Name | HGS Antibody |
|---|---|
| Description | Rabbit polyclonal antibody to HGS |
| Synonyms | Hepatocyte growth factor regulated tyrosine kinase substrate antibody; Hepatocyte growth factor-regulated tyrosine kinase substrate antibody; HGF-regulated tyrosine kinase substrate antibody; HGNC:4897 antibody; HGS antibody; HGS_HUMAN antibody; Hrs antibody; Human growth factor regulated tyrosine kinase substrate antibody; Protein pp110 antibody; ZFYVE8 antibody |
| Host | Rabbit |
| Clonality | Polyclonal |
| Conjugate | Unconjugated |
| Immunogen | Synthesized peptide derived from internal of human HGS. |
| Isotype | IgG |
| Target | HGS |
| Reactivity | Human, Mouse, Rat |
| Applications | ELISA, IF, IHC, WB |
| Form | liquid |
| Diluent Buffer | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Uniprot | O14964 |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Background |
Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation. Asao H., J. Biol. Chem. 272:32785-32791(1997). Lu L., Gene 213:125-132(1998). Scoles D.R., Hum. Mol. Genet. 9:1567-1574(2000). |
| Supplier | Cusabio |
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