| Product Name | Histatin 5 |
|---|---|
| Description | Histatin 5 is a 24 amino acid histidine-rich cationic salivary peptide, formed with histatin 8 from post-translational cleavage of histatin 3. Histatins function as antimicrobial peptides and are important components of the innate immune system. Histatin 5 has broad spectrum antimicrobial action including activity against gram positive and gram negative bacteria, and fungi including Candida albicans and Aspergillus fumigans. Histatin 5 antifungal activity is caused by disruption to mitochondrial respiration through reactive oxygen species (ROS) production. |
| Synonyms | 104339-66-4, AM-091, AM091, DSHAKRHHGYKRKFHEKHHSHRGY, H-DSHAKRHHGYKRKFHEKHHSHRGY-OH, Histatin 5, antimicrobial, innate immune system |
| Molecular Weight | 3036.3 Da |
| Target | Antibacterials,Antifungals |
| Amino Acid Sequence | DSHAKRHHGYKRKFHEKHHSHRGY |
| Form | Freeze dried solid |
| Purity | >95% by HPLC |
| Cas Number | 104339-66-4 |
| Storage | Store desiccated, frozen and in the dark |
| Notes | Modifications: None |
| References |
Mochon and Liu (2008) The antimicrobial peptide histatin-5 causes a spatially restricted disruption on the Candida albicans surface, allowing rapid entry of the peptide into the cytoplasm. PLoS Pathog. 4(10) e1000190 PMID: 18974864Oudhoff et al (2008) Histatins are the major wound-closure stimulating factors in human saliva as identified in a cell culture assay. FASEB J. 22(11) 3805 PMID: 18650243Hemadi et al (2017) Salivary proteins and microbiota as biomarkers for early childhood caries risk assessment. Int. J. Oral Sci. 9, e1 PMID: 29125139 Related areas All antimicrobial peptides >All antifungal agents >All immunology research categories > |
| Supplier | Isca Biochemicals Limited |
All Research Products are sold for laboratory RESEARCH USE ONLY and ARE NOT TO BE USED FOR HUMAN OR ANIMAL THERAPEUTIC OR DIAGNOSTIC APPLICATIONS. The information presented is believed to be accurate; however, said information and products are offered without warranty or guarantee since the ultimate conditions of use and the variability of the materials treated are beyond our control. Nothing disclosed herein is to be construed as a recommendation to use our products in violation of any patents. ARP American Research Products, Inc. does not submit its products for regulatory review by any government body or other organization, and we do not validate them for clinical, therapeutic or diagnostic use, or for safety and effectiveness. You are solely responsible for making sure that the way you use the products complies with applicable laws, regulations and governmental policies and for obtaining all necessary approvals, intellectual property rights, licenses and permissions that you may need related to your use. Under no circumstances shall ARP American Research Products, Inc. be liable for damages, whether consequential, compensatory, incidental or special, strict liability or negligence, breach of warranty or any other theory arising out of the use of the products available from ARP American Research Products, Inc. Nothing contained herein warrants that the use of the products will not infringe on the claims of any patents covering the product itself or the use thereof in combination with other products or in the operation of any process. ARP American Research Products, Inc. disclaims any and all representations or warranties of any kind whatsoever, express or implied, including without limitation any implied warranties of merchantability or fitness for a particular purpose, of non-infringement, or regarding results obtained through the use of any product, whether arising from a statute or otherwise in law or from a course of performance, dealing or usage of trade.
