| Product Name | HP Monoclonal Antibody |
|---|---|
| Description | HP(Haptoglobin) is also named as zonulin and belongs to the peptidase S1 family. HP,a plasma glycoprotein that binds free hemoglobin,has a tetrameric structure of 2 alpha(16 kDa and 9 kDa) and 2 beta(40 kDa) polypeptides that are covalently associated by disulfide bonds. In most species,apart from ruminants,Hp has a molecular mass of 100 kDa,consisting of two subunits of 40 kDa and two subunits of 9 kDa,although in a few species,such as man,genetic variant of Hp forms polymers of higher mass. Recent studies of haptoglobin show that certain oligosaccharide structures predominate in different diseases. For example,a highly-fucosylated structure is found in breast cancer and ovarian cancer,highly-sialylated structures in CrohnÕs disease and highly branched structures in alcoholic liver disease and fucosylated haptoglobin is a good serum marker for pancreatic cancer.. |
| Synonyms | BP,HAPT,haptoglobin,HP,HP2 ALPHA 2,HPA1S |
| Host | Mouse |
| Clone | 905 |
| Immunogen | Fusion protein of HP |
| Isotype | IgG2b |
| Reactivity | Human |
| Applications | ELISA, WB |
| Form | PBS with 0.02% sodium azide, 50% glycerol, PH7.3 |
| Uniprot | P00738 |
| Background | HP(Haptoglobin) is also named as zonulin and belongs to the peptidase S1 family. HP,a plasma glycoprotein that binds free hemoglobin,has a tetrameric structure of 2 alpha(16 kDa and 9 kDa) and 2 beta(40 kDa) polypeptides that are covalently associated by disulfide bonds. In most species,apart from ruminants,Hp has a molecular mass of 100 kDa,consisting of two subunits of 40 kDa and two subunits of 9 kDa,although in a few species,such as man,genetic variant of Hp forms polymers of higher mass. Recent studies of haptoglobin show that certain oligosaccharide structures predominate in different diseases. For example,a highly-fucosylated structure is found in breast cancer and ovarian cancer,highly-sialylated structures in CrohnÕs disease and highly branched structures in alcoholic liver disease and fucosylated haptoglobin is a good serum marker for pancreatic cancer.. |
| Supplier | Elabscience |
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