| Product Name | Hpgd, 1-269aa, Mouse |
|---|---|
| Description | Hpgd, also known as Hydroxyprostaglandin dehydrogenase, is a member of the short-chain dehydrogenases/reductases family. It metabolizes prostaglandins (PGs) to render them. Prostaglandins (PGs) play a crucial role in mediating parturition events, and their synthesis and metabolism are regulated by PGH synthase and 15-hydroxy-PG dehydrogenase (PGDH), respectively. Hpgd, a COX-2 oncogene antagonist, is a TGF-beta-induced suppressor of human gastrointestinal cancers. Recombinant mouse Hpgd protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. |
| Synonyms | 15-Hydroxyprostaglandin dehydrogenase [NAD (+)], 15-PGDH, AV026552 |
| Host | E. coli |
| Molecular Weight | 24 kDa (213aa) |
| Amino Acid Sequence | MGSSHHHHHH SSGLVPRGSH MGSMHVNGKV ALVTGAAQGI GKAFAEALLL HGAKVALVDW NLEAGVKCKA ALDEQFEPQK TLFVQCDVAD QKQLRDTFRK VVDHFGRLDI LVNNAGVNNE KNWEQTLQIN LVSVISGTYL GLDYMSKQNG GEGGIIINMS SLAGLMPVAQ QPVYCASKHG IIGFTRSAAM AANLMKSGVR LNVICPGFVD TPILESIEKE ENMGQYIEYK DQIKAMMKFY GVLHPSTIAN GLINLIEDDA LNGAIMKITA SKGIHFQDYD ISPLLVKAPL TS |
| Tag | His-tag |
| Reactivity | Human |
| Applications | SDS-PAGE |
| Form | Liquid, in 20mM Tris-HCl (pH8.0) containing 0.15M NaCl, 10% glycerol |
| Concentration | 1 mg/ml (determined by Absorbance at 280nm) |
| Purity | > 95% by SDS-PAGE |
| Storage | Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -2°C or -7°C. Avoid repeated freezing and thawing cycles. |
| References | Patel FA. et al., (2003) J Clin Endocrinol Metab. 88(6):2922-33. McKeown KJ. et al., (2003) J Clin Endocrinol Metab. 88(4):1737-41. Yan M. et al., (2004) Proc Natl Acad Sci USA. 101(50):17468-73. |
| Background | Hpgd, also known as Hydroxyprostaglandin dehydrogenase, is a member of the short-chain dehydrogenases/reductases family. It metabolizes prostaglandins (PGs) to render them. Prostaglandins (PGs) play a crucial role in mediating parturition events, and their synthesis and metabolism are regulated by PGH synthase and 15-hydroxy-PG dehydrogenase (PGDH), respectively. Hpgd, a COX-2 oncogene antagonist, is a TGF-beta-induced suppressor of human gastrointestinal cancers. Recombinant mouse Hpgd protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. |
| Supplier | ARP |
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